Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS

Lise Lotte Løbger; Henning Willads Petersen; J. E T Andersen

doi:10.1080/00032710802363248

Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS

Lise Lotte Løbger, Henning Willads Petersen, J. E T Andersen

Chemical & Forensic Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18 min for a single cyanide analysis.

Original language	English
Pages (from-to)	2564-2586
Number of pages	23
Journal	Analytical Letters
Volume	41
Issue number	14
DOIs	https://doi.org/10.1080/00032710802363248
Publication status	Published - Jan 1 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Analytical Chemistry
Electrochemistry
Spectroscopy
Biochemistry, medical

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10.1080/00032710802363248

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AB - An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18 min for a single cyanide analysis.

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Analysis of cyanide in blood by headspace-isotope-dilution-GC-MS

Abstract

All Science Journal Classification (ASJC) codes

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