Antioxidant and antibacterial constituents from Morus nigra

Ofentse Mazimba, Runner R.T. Majinda, Daniel Motlhanka

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


The objective of this study was to isolate and characterize the constituents of the local Morus nigra L. (Black mulberry), to compare its constituents with other studied Mulberries and to evaluate its antioxidative and anti-bacterial activities. The isolated compounds were identified by comparison of spectral data (UV, IR, MS and NMR) with literature values. The stem bark and wood of M. nigra yielded a stilbenoid oxyresveratrol 1, a 2-arylbenzofuran moracin M2, four isoprenylated flavonoids; cyclomorusin 3, morusin 4, kuwanon C5 and a derivative of kuwanon C6, two tritepenes; betulinic acid 7, α-amyrin acetate 8 and a steroidal saponin β-sitosterol-3-O-β-D-glucoside 9. The phenolic isolates showed moderate DPPH radical scavenging activity (EC50 = 23-135 μgml-1) compared to ascorbic acid (EC50 = 41 μgml-1) after 30 min. Compounds 1, 2 and 4 to 6 showed activities against Staphylococcus aureus, Bacillus subtilis, Micrococus flavus, Streptococcus faecalis, Salmonella abony, Pseudomonas aeruginosa.

Original languageEnglish
Article number499407930439
Pages (from-to)751-754
Number of pages4
JournalAfrican Journal of Pharmacy and Pharmacology
Issue number6
Publication statusPublished - Jun 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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