Finasteride significantly reduces acute urinary retention and need for surgery in patients with symptomatic benign prostatic hyperplasia

J. Curtis Nickel, Villis R. Marshall, Claude C. Schulman, Peter Boyle

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

Objectives. A pooled analysis of all available randomized trials with 2-year follow-up data with finasteride and placebo was undertaken to further investigate recent observations that finasteride use may reduce the occurrence of acute urinary retention (AUR) and benign prostatic hyperplasia (BPH)-related surgical intervention. Methods. Occurrences of AUR and surgical intervention were examined by treatment group in a pooled series of 4222 men with moderately symptomatic BPH. Results. In total, 81 occurrences of AUR were reported, 24 (1.1%) of 2113 in the finasteride group and 57 (2.7%) of 2109 in the placebo group. The hazard ratio was consistent in all three studies, with a 57% decrease in the hazard rate for occurrence of AUR with finasteride compared with that for placebo present in the pooled data set over the 2-year study period (P
Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalUrology
Volume49
Issue number6
DOIs
Publication statusPublished - 1997
Externally publishedYes

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