Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted4-[2′-(O-diarylacyl)hydroxyphenyl]-2- azetidinones

G. S. Singh; T. Pheko

Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted4-[2′-(O-diarylacyl)hydroxyphenyl]-2- azetidinones

G. S. Singh, T. Pheko

Chemical & Forensic Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Treatment of the 1,3,3-trisubstituted 4-[2′-(O-diarylacyl)- hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2′-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, ¹H and ¹³C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR ( ¹H-¹³C COSY) spectra. The antibacterial and antifungal activities of the products are reported.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume	47
Issue number	1
Publication status	Published - Jan 2008

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
Organic Chemistry

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AU - Pheko, T.

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AB - Treatment of the 1,3,3-trisubstituted 4-[2′-(O-diarylacyl)- hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2′-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, 1H and 13C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR ( 1H-13C COSY) spectra. The antibacterial and antifungal activities of the products are reported.

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Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted4-[2′-(O-diarylacyl)hydroxyphenyl]-2- azetidinones

Abstract

All Science Journal Classification (ASJC) codes

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