Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

N. Ali; Y. Kousar; T. I. Okpalugo; V. Singh; M. Pease; A. A. Ogwu; J. Gracio; E. Titus; E. I. Meletis; M. J. Jackson

doi:10.1016/j.tsf.2005.12.023

Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

N. Ali, Y. Kousar, T. I. Okpalugo, V. Singh, M. Pease, A. A. Ogwu, J. Gracio, E. Titus, E. I. Meletis, M. J. Jackson

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Thin Solid Films
Volume	515
Issue number	1
DOIs	https://doi.org/10.1016/j.tsf.2005.12.023
Publication status	Published - Sept 25 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1016/j.tsf.2005.12.023

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title = "Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications",

abstract = "In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.",

author = "N. Ali and Y. Kousar and Okpalugo, {T. I.} and V. Singh and M. Pease and Ogwu, {A. A.} and J. Gracio and E. Titus and Meletis, {E. I.} and Jackson, {M. J.}",

note = "Funding Information: Y. Kousar would like to thank FCT (Portugal) for the financial support (SFRH/BD/8093/2002).",

year = "2006",

month = sep,

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doi = "10.1016/j.tsf.2005.12.023",

language = "English",

volume = "515",

pages = "59--65",

journal = "Thin Solid Films",

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T1 - Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

AU - Ali, N.

AU - Kousar, Y.

AU - Okpalugo, T. I.

AU - Singh, V.

AU - Pease, M.

AU - Ogwu, A. A.

AU - Gracio, J.

AU - Titus, E.

AU - Meletis, E. I.

AU - Jackson, M. J.

N1 - Funding Information: Y. Kousar would like to thank FCT (Portugal) for the financial support (SFRH/BD/8093/2002).

PY - 2006/9/25

Y1 - 2006/9/25

N2 - In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.

AB - In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.

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SN - 0040-6090

VL - 515

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JO - Thin Solid Films

JF - Thin Solid Films

IS - 1

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Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

Abstract

All Science Journal Classification (ASJC) codes

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