TY - JOUR
T1 - Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application
AU - Ali, N.
AU - Kousar, Y.
AU - Gracio, J.
AU - Titus, E.
AU - Okpalugo, T. I.
AU - Singh, V.
AU - Pease, M.
AU - Ogwu, A. A.
AU - Meletis, E. I.
AU - Ahmed, W.
AU - Jackson, M. J.
PY - 2006/4
Y1 - 2006/4
N2 - In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.
AB - In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.
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U2 - 10.1361/105994906X95931
DO - 10.1361/105994906X95931
M3 - Article
AN - SCOPUS:33645981607
SN - 1059-9495
VL - 15
SP - 230
EP - 235
JO - Journal of Materials Engineering and Performance
JF - Journal of Materials Engineering and Performance
IS - 2
ER -