Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application

N. Ali, Y. Kousar, J. Gracio, E. Titus, T. I. Okpalugo, V. Singh, M. Pease, A. A. Ogwu, E. I. Meletis, W. Ahmed, M. J. Jackson

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalJournal of Materials Engineering and Performance
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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