Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application

N. Ali; Y. Kousar; J. Gracio; E. Titus; T. I. Okpalugo; V. Singh; M. Pease; A. A. Ogwu; E. I. Meletis; W. Ahmed; M. J. Jackson

doi:10.1361/105994906X95931

Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application

N. Ali, Y. Kousar, J. Gracio, E. Titus, T. I. Okpalugo, V. Singh, M. Pease, A. A. Ogwu, E. I. Meletis, W. Ahmed, M. J. Jackson

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.

Original language	English
Pages (from-to)	230-235
Number of pages	6
Journal	Journal of Materials Engineering and Performance
Volume	15
Issue number	2
DOIs	https://doi.org/10.1361/105994906X95931
Publication status	Published - Apr 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1361/105994906X95931

Cite this

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title = "Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application",

abstract = "In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.",

author = "N. Ali and Y. Kousar and J. Gracio and E. Titus and Okpalugo, {T. I.} and V. Singh and M. Pease and Ogwu, {A. A.} and Meletis, {E. I.} and W. Ahmed and Jackson, {M. J.}",

year = "2006",

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doi = "10.1361/105994906X95931",

language = "English",

volume = "15",

pages = "230--235",

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T1 - Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application

AU - Ali, N.

AU - Kousar, Y.

AU - Gracio, J.

AU - Titus, E.

AU - Okpalugo, T. I.

AU - Singh, V.

AU - Pease, M.

AU - Ogwu, A. A.

AU - Meletis, E. I.

AU - Ahmed, W.

AU - Jackson, M. J.

PY - 2006/4

Y1 - 2006/4

N2 - In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.

AB - In this investigation, Cr-modified diamond-like carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr-DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma-assisted processing (IPAP) system. The three samples consisted of the following Cr contents: 1, 5, and 10 at.%. The biological response of human microvascular endothelial cells (HMV-EC), seeded on Cr-DLC films, was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, x-ray diffraction, scanning electron microscopy, secondary ion mass spectroscopy, and by the contact angle technique. Endothelial cell adhesion and growth were found to be affected by changing the Cr content of Cr-DLC films.

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ER -

Human microvascular endothelial cell seeding on Cr-DLC thin films for heart valve application

Abstract

All Science Journal Classification (ASJC) codes

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