Myrothamnus flabellifolius attenuates streptozotocinhigh energy diet-induced type 2 diabetes in male sprague dawley rats

Kwape Tebogo, Padmaja Chaturvedi, Kabo Masisi, Runner Majinda

Research output: Contribution to journalArticlepeer-review


Several medicinal plants have anti-diabetic properties and can be considered as an alternative therapy
because of their actions which are like those of conventional antidiabetic drugs. In this study, we
investigated Myrothamnus flabellifolius (MF) ethanol: water (70:30) extract for its possible anti-diabetic
potential in streptozotocin-high energy diet (STZ-HED) induced type 2 diabetes mellitus (T2DM) rats and
its possible mechanisms of action. Diabetic rats were divided into MF-50, MF-100, MF200, MF-300, MF400, and Metformin (MET)-500 groups, where the numbers represent doses in that were
administered to the groups. Normal (NC) and diabetic (DC) controls were administered distilled water.
The animals had their fasting blood glucose levels and body weights determined weekly for 21 days.
Blood samples, liver, pancreas, and muscle were collected and used for biochemical and histological
examination. Our study showed that MF extract lowered glucose levels, body weight, glycated
hemoglobin, thiobarbituric acid reactive substances, serum glutamate pyruvate transaminase, serum
glutamate oxaloacetate transaminase, Homeostatic model assessment of insulin resistance, and
alkaline phosphatase (p<0.05; p<0.01) in T2DM. While adiponectin, catalase, leptin, lipid profile, insulin
Homeostatic model of assessment of β cell function, and superoxide dismutase levels were elevated
(p<0.05; p<0.01). Furthermore, MF extract preserved both the liver and the islets structure of T2DM rats
and enhanced muscle glucose transporter 4 (GLUT 4) expression. M. flabellifolius extract normalized
blood glucose and body weight in T2DM. Further investigations are needed to explore other possible
mechanisms of action and clinical potential of MF extracts.
Original languageEnglish
Article numberB5F1F3965562
Pages (from-to)625-637
Number of pages13
JournalJournal of Medicinal Plants Research
Issue number12
Publication statusPublished - Oct 9 2020


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