TY - JOUR
T1 - Plant-made HIV vaccines and potential candidates
AU - Trémouillaux-Guiller , Jocelyne
AU - Moustafa, Khaled
AU - Hefferon, Kathleen
AU - Gaobotse, Goabaone
AU - Abdullah, Makhzoum
PY - 2020
Y1 - 2020
N2 - Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.
AB - Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85079105822&origin=resultslist&sort=plf-f&src=s&st1=Plant-made+HIV+vaccines+and+potential+candidates&st2=&sid=05f1b10093f6615afbb9ba1047ee2936&sot=b&sdt=b&sl=63&s=TITLE-ABS-KEY%28Plant-made+HIV+vaccines+and+potential+candidates%29&relpos=0&citeCnt=1&searchTerm=
UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-85079105822&src=s&imp=t&sid=d365c6f11770086a660c273972a8d0b0&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=2c170abccc1873dbb83d89cb2b9244da
U2 - 10.1016/j.copbio.2020.01.004
DO - 10.1016/j.copbio.2020.01.004
M3 - Review article
SN - 0958-1669
VL - 61
SP - 209
EP - 216
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -
