Platelet adhesion on silicon modified hydrogenated amorphous carbon films

T. I.T. Okpalugo; A. A. Ogwu; P. D. Maguire; J. A.D. McLaughlin

doi:10.1016/S0142-9612(03)00494-0

Platelet adhesion on silicon modified hydrogenated amorphous carbon films

T. I.T. Okpalugo, A. A. Ogwu, P. D. Maguire, J. A.D. McLaughlin

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.

Original language	English
Pages (from-to)	239-245
Number of pages	7
Journal	Biomaterials
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/S0142-9612(03)00494-0
Publication status	Published - Jan 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/S0142-9612(03)00494-0

Cite this

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title = "Platelet adhesion on silicon modified hydrogenated amorphous carbon films",

abstract = "We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.",

author = "Okpalugo, {T. I.T.} and Ogwu, {A. A.} and Maguire, {P. D.} and McLaughlin, {J. A.D.}",

note = "Funding Information: The authors acknowledge the following people, Prof. D.G. Hirst, Dr. E. McKenna; Dr. S.W.B. Irwin, Dr. Don Saville, Dr. Tony Magee, Prof. N.M. Brown and Dr. C.A. Anderson of the University of Ulster for the provision of facilities. T.O. acknowledges a University scholarship.",

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doi = "10.1016/S0142-9612(03)00494-0",

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T1 - Platelet adhesion on silicon modified hydrogenated amorphous carbon films

AU - Okpalugo, T. I.T.

AU - Ogwu, A. A.

AU - Maguire, P. D.

AU - McLaughlin, J. A.D.

N1 - Funding Information: The authors acknowledge the following people, Prof. D.G. Hirst, Dr. E. McKenna; Dr. S.W.B. Irwin, Dr. Don Saville, Dr. Tony Magee, Prof. N.M. Brown and Dr. C.A. Anderson of the University of Ulster for the provision of facilities. T.O. acknowledges a University scholarship.

PY - 2004/1

Y1 - 2004/1

N2 - We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.

AB - We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.

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JO - Biomaterials

JF - Biomaterials

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Platelet adhesion on silicon modified hydrogenated amorphous carbon films

Abstract

All Science Journal Classification (ASJC) codes

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