TY - JOUR
T1 - Prevalence and factors associated with microalbuminuria in pediatric patients with type 1 diabetes mellitus at a large tertiary-level hospital in botswana
AU - Ramaphane, Tshireletso
AU - Gezmu, Alemayehu M.
AU - Tefera, Endale
AU - Gabaitiri, Lesego
AU - Nchingane, Seeletso
AU - Matsheng-Samuel, Motlalekgomo
AU - Joel, Dipesalema
N1 - Funding Information:
The authors would like to acknowledge Dr Jonathan Strysko for copy editing the manuscript and the parents and patients who took part in this study. The authors would like to acknowledge the support of Children’s Hospital of Philadelphia-Global Health centre (CHOP-Global) for payment of article publishing charges.
Publisher Copyright:
© 2021 Ramaphane et al.
PY - 2021
Y1 - 2021
N2 - Introduction: Microalbuminuria is considered the earliest sign of diabetic nephropathy among patients with type 1 diabetes mellitus (T1DM). The prevalence of microalbuminuria among African children with T1DM is reported to be high, yet its prevalence and population-specific risk factors in Botswana are not known. Aim: This study aimed to determine the prevalence of microalbuminuria among children and young adults with T1DM in Botswana and identify factors associated with microalbuminuria in this population. Methods: A retrospective cross-sectional study was conducted on 127 T1DM patients aged <24 years followed at a pediatric endocrinology clinic in Botswana from 2010 to 2017. Clinical, laboratory, and demographic data were collected using chart review and patient surveys. Descriptive statistics were reported as mean and standard deviation for continuous variables, and frequency and percentage for categorical variables. Prevalence of microalbu-minuria was calculated as a simple proportion. Group comparison was done using two-sample independent t-test, X2-test, or Fisher’s exact test and logistic regression to assess for associations. Level of significance was set at p<0.05. Results: There were a total of 71 (55.9%) females. The mean age was 18.7 (±5) years and mean duration of T1DM was 6.6 (±4.6) years. Most study participants were of African descent. The prevalence of microalbuminuria was 28.3%. Group comparison revealed gender (p= 0.040), duration of diabetes (p= 0.002), systolic blood pressure (p=0.003), baseline glycated hemoglobin (HbA1c) (p=0.009) and Tanner’s stage (p=008) to be significantly associated with microalbuminuria. On binary logistic regression, only gender (p=0.039) and baseline HbA1c (p=0.039) were independently associated with the presences of microalbuminuria. Conclusion: This study identified a high prevalence of microalbuminuria among children and young adults with T1DM in Botswana and reaffirms the importance of early detection, glycemic control, and regular screening to prevent diabetic nephropathy.
AB - Introduction: Microalbuminuria is considered the earliest sign of diabetic nephropathy among patients with type 1 diabetes mellitus (T1DM). The prevalence of microalbuminuria among African children with T1DM is reported to be high, yet its prevalence and population-specific risk factors in Botswana are not known. Aim: This study aimed to determine the prevalence of microalbuminuria among children and young adults with T1DM in Botswana and identify factors associated with microalbuminuria in this population. Methods: A retrospective cross-sectional study was conducted on 127 T1DM patients aged <24 years followed at a pediatric endocrinology clinic in Botswana from 2010 to 2017. Clinical, laboratory, and demographic data were collected using chart review and patient surveys. Descriptive statistics were reported as mean and standard deviation for continuous variables, and frequency and percentage for categorical variables. Prevalence of microalbu-minuria was calculated as a simple proportion. Group comparison was done using two-sample independent t-test, X2-test, or Fisher’s exact test and logistic regression to assess for associations. Level of significance was set at p<0.05. Results: There were a total of 71 (55.9%) females. The mean age was 18.7 (±5) years and mean duration of T1DM was 6.6 (±4.6) years. Most study participants were of African descent. The prevalence of microalbuminuria was 28.3%. Group comparison revealed gender (p= 0.040), duration of diabetes (p= 0.002), systolic blood pressure (p=0.003), baseline glycated hemoglobin (HbA1c) (p=0.009) and Tanner’s stage (p=008) to be significantly associated with microalbuminuria. On binary logistic regression, only gender (p=0.039) and baseline HbA1c (p=0.039) were independently associated with the presences of microalbuminuria. Conclusion: This study identified a high prevalence of microalbuminuria among children and young adults with T1DM in Botswana and reaffirms the importance of early detection, glycemic control, and regular screening to prevent diabetic nephropathy.
UR - http://www.scopus.com/inward/record.url?scp=85121986021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121986021&partnerID=8YFLogxK
U2 - 10.2147/DMSO.S322847
DO - 10.2147/DMSO.S322847
M3 - Article
AN - SCOPUS:85121986021
SN - 1178-7007
VL - 14
SP - 4415
EP - 4422
JO - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
JF - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
ER -
