TY - JOUR
T1 - Setting a baseline for global urban virome surveillance in sewage
AU - The Global Sewage Surveillance project consortium
AU - Nieuwenhuijse, David F.
AU - Oude Munnink, Bas B.
AU - Phan, My V.T.
AU - Hendriksen, Rene S.
AU - Bego, Artan
AU - Rees, Catherine
AU - Neilson, Elizabeth Heather
AU - Coventry, Kris
AU - Collignon, Peter
AU - Allerberger, Franz
AU - Rahube, Teddie O.
AU - Oliveira, Guilherme
AU - Ivanov, Ivan
AU - Sopheak, Thet
AU - Vuthy, Yith
AU - Yost, Christopher K.
AU - Tabo, Djim adjim
AU - Cuadros-Orellana, Sara
AU - Ke, Changwen
AU - Zheng, Huanying
AU - Baisheng, Li
AU - Jiao, Xiaoyang
AU - Donado-Godoy, Pilar
AU - Coulibaly, Kalpy Julien
AU - Hrenovic, Jasna
AU - Jergović, Matijana
AU - Karpíšková, Renáta
AU - Elsborg, Bodil
AU - Legesse, Mengistu
AU - Eguale, Tadesse
AU - Heikinheimo, Annamari
AU - Villacis, Jose Eduardo
AU - Sanneh, Bakary
AU - Malania, Lile
AU - Nitsche, Andreas
AU - Brinkmann, Annika
AU - Saba, Courage Kosi Setsoafia
AU - Kocsis, Bela
AU - Solymosi, Norbert
AU - Thorsteinsdottir, Thorunn R.
AU - Hatha, Abdulla Mohamed
AU - Alebouyeh, Masoud
AU - Morris, Dearbhaile
AU - O’Connor, Louise
AU - Cormican, Martin
AU - Moran-Gilad, Jacob
AU - Battisti, Antonio
AU - Alba, Patricia
AU - Shakenova, Zeinegul
AU - Kiiyukia, Ciira
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.
AB - The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.
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U2 - 10.1038/s41598-020-69869-0
DO - 10.1038/s41598-020-69869-0
M3 - Article
C2 - 32792677
AN - SCOPUS:85089383261
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13748
ER -