The Potential Anti-Diabetic Effects of Saskatoon Berry in Experimental Mouse Models

Mohammed H Moghadasian, Kabo Masisi, Khuong Le, Trust Beta, Gerry X Shen, G Fischer

Research output: Contribution to journalArticlepeer-review


We previously reported that Saskatoon-Berry-Powder (SBP) might have beneficial effects on vascular inflammation and endoplasmic reticulum stress in experimental animals. In a pilot study, we tested various oral doses of SBP and learned that the 5% (w/w) dose seems to have the best effects. This study investigated the impact of dietary intake of SBP at 5% (w/w) on several biochemical factors pertaining to body weight gain, glucose metabolism; lipids, inflammation and organ function over a 4-week study period. The db/db mouse model of type 2 diabetes and their wild-type counterparts (C57BL/6J mice) were used. Body weight, food-intake, whole blood glucose, and plasma total cholesterol levels were significantly higher in the db/db mice as compared with those in C57BL/6J mice. Consumption of SBP did not change the animals’ body weight gain rates or food consumption in either animal model over the experimental course. The SBP-treated db/db mice showed approximately 30% reductions in their blood and urine glucose levels as compared to those in nontreated db/db mice over 4 weeks of experiment. Furthermore, the db/db mice show a different inflammatory-marker profile as compared to that in C57BL/6J mice; treatment with SBP was associated with changes in such profiles mainly in db/db mice. It is not clear which component(s) of SBP is responsible for the effects observed in this study. Future studies warrant identification of such functional components of SBP.
Original languageEnglish
Article number1111
Pages (from-to)1-5
Number of pages5
JournalAustin Journal of Nutrition and Food Sciences
Issue number1
Publication statusPublished - Jan 8 2019


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