TY - GEN
T1 - Understanding the functionality of multiplexed sensors in order to aid design and enhance performance
AU - Moodley, K.
AU - Land, K. J.
AU - Muzenda, E.
N1 - Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - Multiplexed sensors enable simultaneous detection of disease biomarkers and environmental contaminants using a single test. Test results feature multiple signals, which if unclear, can result in misdiagnosis. This work studies the phenomenon of weakening signal intensities on multiplexed lateral flow tests. Results indicate that physical analyte entrapment has minimal impact on this phenomenon, which is influenced more, by the quantity of analyte in the sample and the positioning of the test line. Recommendations are made on the maximum number of test lines that should be employed to avoid reduced signal intensities, and the benefits of paper based microfluidics are discussed.
AB - Multiplexed sensors enable simultaneous detection of disease biomarkers and environmental contaminants using a single test. Test results feature multiple signals, which if unclear, can result in misdiagnosis. This work studies the phenomenon of weakening signal intensities on multiplexed lateral flow tests. Results indicate that physical analyte entrapment has minimal impact on this phenomenon, which is influenced more, by the quantity of analyte in the sample and the positioning of the test line. Recommendations are made on the maximum number of test lines that should be employed to avoid reduced signal intensities, and the benefits of paper based microfluidics are discussed.
UR - https://www.scopus.com/pages/publications/84983314871
UR - https://www.scopus.com/pages/publications/84983314871#tab=citedBy
M3 - Conference contribution
AN - SCOPUS:84983314871
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1640
EP - 1642
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -